Ana Pombo - Short Bio

ana pombo

Ana Pombo investigates how the 3D folding of chromosomes influences gene expression in mammalian development and disease, and how poising of RNA polymerase II is regulated to prime genes for future activation. Her laboratory showed that Polycomb repression is associated with RNA polymerase II poising and developed high-resolution cryoFISH approaches to study spatial relationships between genomic regions and nuclear landmarks. More recently, her laboratory has developed Genome Architecture Mapping, an orthogonal ligation-free approach to map chromatin contacts genome-wide.